Ethyl 2-(diethoxymethyl)thiazole-4-carboxylate → Ethyl 2-formyl-1,3-thiazole-4-carboxylate

HRID 244652ノート

反応式

HRID 244652 の反応式
C([O:3][CH:4](OCC)[C:5]1[S:6][CH:7]=[C:8]([C:10]([O:12][CH2:13][CH3:14])=[O:11])[N:9]=1)C>Cl.CC(C)=O>[CH:4]([C:5]1[S:6][CH:7]=[C:8]([C:10]([O:12][CH2:13][CH3:14])=[O:11])[N:9]=1)=[O:3]

参加物

4

反応物 1

HCID 16220290Ethyl 2-(diethoxymethyl)thiazole-4-carboxylate

生成物 1

HCID 11355896Ethyl 2-formyl-1,3-thiazole-4-carboxylate収率 97.6%

試薬・触媒・溶媒 2

HCID 180Acetone溶媒HCID 313Hydrochloric Acid溶媒

実験手順

A solution of ethyl 2-[bis(ethyloxy)methyl]-1,3-thiazole-4-carboxylate (455 mg) in 10% 1M hydrochloric acid in acetone (50 ml) was heated at reflux for 1 h. The mixture was concentrated in vacuo, taken up in DCM (20 ml) and washed with saturated sodium bicarbonate solution (10 ml). The organic layer was separated using a hydrophobic frit and evaporated to give the title compound (317 mg) as a yellow solid.

後処理

  1. temperatureat reflux for 1 h
  2. concentrationThe mixture was concentrated in vacuo
  3. washwashed with saturated sodium bicarbonate solution (10 ml)
  4. customThe organic layer was separated
  5. customevaporated

出典と根拠

ORDレコード
ord-8b26753199ef4372a0c393a59c494455
出典データセット
uspto-grants-2014_02
特許番号
US08658635B2

反応ノート

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