Hydrochloric Acid → 2-Aminothiazole-4-carboxylic acid

HRID 244658ノート

反応式

HRID 244658 の反応式
[NH2:1][C:2]1[S:3][CH:4]=[C:5]([C:7]([O:9]CC)=[O:8])[N:6]=1.Cl>O1CCOCC1>[NH2:1][C:2]1[S:3][CH:4]=[C:5]([C:7]([OH:9])=[O:8])[N:6]=1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 73216Ethyl 2-aminothiazole-4-carboxylate

生成物 1

HCID 15018822-Aminothiazole-4-carboxylic acid収率 119.5%

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

To a solution of ethyl 2-amino-1,3-thiazole-4-carboxylate (150 mg) (for example available, from Maybridge Chemical Company) in 1,4-dioxane (3 ml) was added 2M hydrochloric acid (2 ml) and the mixture heated at reflux under nitrogen for 70 h. The mixture was cooled to room temperature and the solvent removed in vacuo. Toluene (15 ml) was added and the solvent removed in vacuo to give a solid that was dried in an vacuum oven overnight to give the title compound (150 mg) as a brown solid.

後処理

  1. temperaturethe mixture heated
  2. temperatureat reflux under nitrogen for 70 h
  3. customthe solvent removed in vacuo
  4. additionToluene (15 ml) was added
  5. customthe solvent removed in vacuo
  6. customto give a solid
  7. customthat was dried in an vacuum oven overnight

出典と根拠

ORDレコード
ord-bb195289752f4faaa9ff5bf8e074e332
出典データセット
uspto-grants-2014_02
特許番号
US08658635B2

反応ノート

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