Hydrochloric Acid → 1-ethyl-4-fluoro-1H-pyrazole-5-carboxylic acid
反応式
[CH2:1]([N:3]1[C:7]([C:8]([O:10]CC)=[O:9])=[C:6]([F:13])[CH:5]=[N:4]1)[CH3:2].Cl>O1CCOCC1>[CH2:1]([N:3]1[C:7]([C:8]([OH:10])=[O:9])=[C:6]([F:13])[CH:5]=[N:4]1)[CH3:2]参加物
4
実験手順
To a solution of ethyl 1-ethyl-4-fluoro-1H-pyrazole-5-carboxylate (67 mg) in 1,4-dioxane (3 ml) was added 2M hydrochloric acid (2 ml) was added and the mixture was heated at reflux under nitrogen for 120 h. The mixture was cooled to room temperature and the solvent was removed in vacuo. Toluene (15 ml) was added and the solvent was removed in vacuo to give a solid that was dried in a vacuum oven overnight to give the title compound (26 mg) as a brown solid.
後処理
- additionwas added
- temperaturethe mixture was heated
- temperatureat reflux under nitrogen for 120 h
- customthe solvent was removed in vacuo
- additionToluene (15 ml) was added
- customthe solvent was removed in vacuo
- customto give a solid
- customthat was dried in a vacuum oven overnight
出典と根拠
- ORDレコード
- ord-11e4c56967834f96826b35e474adafa2
- 出典データセット
- uspto-grants-2014_02
- 特許番号
- US08658635B2
反応ノート
読み込み中…