Hydrochloric Acid → 2-Amino-5-isopropylthiazole-4-carboxylic acid
反応式
[NH2:1][C:2]1[S:3][C:4]([CH:11]([CH3:13])[CH3:12])=[C:5]([C:7]([O:9]C)=[O:8])[N:6]=1.Cl>O1CCOCC1>[NH2:1][C:2]1[S:3][C:4]([CH:11]([CH3:13])[CH3:12])=[C:5]([C:7]([OH:9])=[O:8])[N:6]=1参加物
4
反応条件
- 温度
- 110 °C
実験手順
To a solution of methyl 2-amino-5-(1-methylethyl)-1,3-thiazole-4-carboxylate (220 mg) (for example, available from ABCR) in 1,4-dioxane (5 ml) was added 2M hydrochloric acid (5 ml) and the mixture heated at 110° C. for 72 h. The mixture was evaporated in vacuo to give the title compound (240 mg) as a pale yellow solid.
後処理
- customThe mixture was evaporated in vacuo
出典と根拠
- ORDレコード
- ord-75d90a6cef4a4fc39f866710bd04e50c
- 出典データセット
- uspto-grants-2014_02
- 特許番号
- US08658635B2
反応ノート
読み込み中…