Thionyl Chloride → 1,4-Dimethyl-1H-pyrazole-3-carbonyl chloride

関与物質

反応条件

反応手順

Thionyl chloride (4 ml) was added to 1,4-dimethyl-1H-pyrazole-3-carboxylic acid (0.5 g) and the reaction was heated at 80° C. for 2 h. Further thionyl chloride (2 ml) was added and the reaction was heated at 80° C. for 1 h. The reaction was evaporated, then azeotroped with toluene to give title compound, 511 mg.

情報源と証拠