N-methyl-2-oxoindoline-5-sulfonamide → 2-Methyl-5-(5-methylsulfamoyl-2-oxo-1,2-dihydroindol-3-ylidenemethyl)-4-(3-morpholin-4-ylpropyl)-1H-pyrrole-3-carboxylic Acid Ethyl Ester

HRID 24473

反応式

HRID 24473 の反応式
[CH3:1][NH:2][S:3]([C:6]1[CH:7]=[C:8]2[C:12](=[CH:13][CH:14]=1)[NH:11][C:10](=[O:15])[CH2:9]2)(=[O:5])=[O:4].[CH2:16]([O:18][C:19]([C:21]1[C:25]([CH2:26][CH2:27][CH2:28][N:29]2[CH2:34][CH2:33][O:32][CH2:31][CH2:30]2)=[C:24]([CH:35]=O)[NH:23][C:22]=1[CH3:37])=[O:20])[CH3:17]>>[CH2:16]([O:18][C:19]([C:21]1[C:25]([CH2:26][CH2:27][CH2:28][N:29]2[CH2:34][CH2:33][O:32][CH2:31][CH2:30]2)=[C:24]([CH:35]=[C:9]2[C:8]3[C:12](=[CH:13][CH:14]=[C:6]([S:3](=[O:5])(=[O:4])[NH:2][CH3:1])[CH:7]=3)[NH:11][C:10]2=[O:15])[NH:23][C:22]=1[CH3:37])=[O:20])[CH3:17]

参加物

3

反応物 2

HCID 10176909N-methyl-2-oxoindoline-5-sulfonamideHCID 537709155-formyl-2-methyl-4-(3-morpholin-4-ylpropyl)-1H-pyrrole-3-carboxylic acid ethyl ester

生成物 1

HCID 538401812-Methyl-5-(5-methylsulfamoyl-2-oxo-1,2-dihydroindol-3-ylidenemethyl)-4-(3-morpholin-4-ylpropyl)-1H-pyrrole-3-carboxylic Acid Ethyl Ester

実験手順

2-Oxo-2,3-dihydro-1H-indole-5-sulfonic acid methylamide was stirred with 5-formyl-2-methyl-4-(3-morpholin-4-ylpropyl)-1H-pyrrole-3-carboxylic acid ethyl ester overnight at room temperature to give the title compound.

出典と根拠

ORDレコード
ord-b5eec24dd7e64e16bf2b3d763ece6f7c
出典データセット
uspto-grants-2005_02
特許番号
US06855730B2

関連ノート

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