Sulfuric Acid → HCID 22238302、化合物

HRID 244762

反応式

HRID 244762 の反応式
[CH2:1]([C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[CH2:9][CH3:10])[CH3:2].[C:11](Cl)(=[O:14])[CH2:12][CH3:13].[Al+3].[Cl-:17].[Cl-].[Cl-].S(=O)(=O)(O)O>[N+](C)([O-])=O>[Cl:17][CH2:13][CH2:12][C:11]([C:7]1[CH:6]=[CH:5][C:4]([CH2:9][CH3:10])=[C:3]([CH2:1][CH3:2])[CH:8]=1)=[O:14]

参加物

6

反応物 4

HCID 1118Sulfuric AcidHCID 86571,2-DiethylbenzeneHCID 62324Propionyl chlorideHCID 6451240Aluminum(III) Chloride

生成物 1

HCID 22238302HCID 22238302、化合物

試薬・触媒・溶媒 1

HCID 6375Nitromethane溶媒

実験手順

1,2-Diethylbenzene (10.9 g, 74.6 mmol) and propionyl chloride (9.7 g, 74.6 mmol) are added dropwise to AlCl3 (22.3 g, 167.8 mmol) in nitromethane (75 mL) over 30 min. The reaction mixture is stirred at room temperature for 2 hours, after which 70 g of ice and 14 mL concentrated sulphuric acid are added. The aqueous phase is extracted with ether, and the combined organic phases extracted with 2N HCl and saturated aqueous NaCl. The organic phase is further treated with activated charcoal, magnesium sulphate, and filtered, and the solvent removed in vacuo.

後処理

  1. extractionThe aqueous phase is extracted with ether
  2. extractionthe combined organic phases extracted with 2N HCl and saturated aqueous NaCl
  3. additionThe organic phase is further treated with activated charcoal, magnesium sulphate
  4. filtrationfiltered
  5. customthe solvent removed in vacuo

出典と根拠

ORDレコード
ord-d49820e5415d42d08eeba64a59216717
出典データセット
uspto-grants-2014_02
特許番号
US08658673B2

関連ノート

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