Potassium Hydroxide → 2-Amino-5,6-bis(methoxymethyl)indane

HRID 244765

反応式

HRID 244765 の反応式
[OH-].[K+].FC(F)(F)C([NH:7][CH:8]1[CH2:16][C:15]2[C:10](=[CH:11][C:12]([CH2:20][O:21][CH3:22])=[C:13]([CH2:17][O:18][CH3:19])[CH:14]=2)[CH2:9]1)=O>O.CO>[NH2:7][CH:8]1[CH2:9][C:10]2[C:15](=[CH:14][C:13]([CH2:17][O:18][CH3:19])=[C:12]([CH2:20][O:21][CH3:22])[CH:11]=2)[CH2:16]1

参加物

5

反応物 2

HCID 14797Potassium HydroxideHCID 224992202-(Trifluoroacetylamino)-5,6-bis(methoxymethyl)indane

生成物 1

HCID 668228442-Amino-5,6-bis(methoxymethyl)indane

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 962Water溶媒

実験手順

A solution of potassium hydroxide (150 mg, 2.60 mmol) in water (0.5 ml) is added to a solution of 2-(trifluoroacetylamino)-5,6-bis(methoxymethyl)indane (240 mg, 0.75 mmol) in methanol (3 mL) and the mixture is heated at reflux for 2.5 hours. The solvent was removed in vacuo and the residue is partitioned between aqueous sodium hydroxide (10 mL) and ethyl acetate (20 mL). The organic extract is dried (MgSO4) and the solvent is removed in vacuo to leave the product as a dark oil.

後処理

  1. temperaturethe mixture is heated
  2. temperatureat reflux for 2.5 hours
  3. customThe solvent was removed in vacuo
  4. customthe residue is partitioned between aqueous sodium hydroxide (10 mL) and ethyl acetate (20 mL)
  5. extractionThe organic extract
  6. dry with materialis dried (MgSO4)
  7. customthe solvent is removed in vacuo

出典と根拠

ORDレコード
ord-46c1ada1240549c09f400d705806e93b
出典データセット
uspto-grants-2014_02
特許番号
US08658673B2

関連ノート

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