関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 8-benzyloxy-5-bromo-3-methyl-1H-quinolin-2-one | HCID 22499211 | — |
| 反応物 | Tri(butyl)vinyltin | HCID 53438229 | — |
| 触媒 | Tetrakis(triphenylphosphine)palladium | HCID 11979704 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | 8-Benzyloxy-3-methyl-5-vinyl-1H-quinolin-2-one | HCID 22499178 | — |
反応手順
Palladium tetrakis(triphenylphosphine) (30 mg) is added to a solution of 8-benzyloxy-5-bromo-3-methyl-1H-quinolin-2-one (239 mg) and tributylvinyltin (203 μL) in toluene (7 mL) at room temperature. The reaction mixture is heated for 2 hours at 100° C., cooled to room temperature, evaporated and the product purified by flash column chromatography on silica gel, eluting with 2% ethyl acetate in dichloromethane.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08658673B2 |
|---|
| 出典データセット | uspto-grants-2014_02 |
|---|
| ORD ID | ord-90cd000ba6454cce95298836ebc318df |
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| 出典メモ | uspto-grants-2014_02 |
|---|
