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Piperidine → 5-methyl-3-(3-methyl-1H-indol-2-ylmethylene)-1,3-dihydroindol-2-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Piperidine | HCID 8082 | — |
| 反応物 | 3-Methyl-1H-indole-2-carbaldehyde | HCID 277260 | — |
| 反応物 | 5-Methylindolin-2-one | HCID 5325716 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 5-methyl-3-(3-methyl-1H-indol-2-ylmethylene)-1,3-dihydroindol-2-one | HCID 53755378 | 74% |
反応手順
A mixture of 5-methyl-2-oxindole (59 mg), 3-methylindole-2-carbaldehyde (56 mg) and piperidine (30 mg) in ethanol(1 mL) was held in a sealed tube at 90° C. overnight. The mixture was cooled to room temperature. The solid was collected by vacuum filtration, washed with cold ethanol and dried in a vacuum oven to give 72 mg (74%) of 5-methyl-3-(3-methyl-1H-indol-2-ylmethylene)-1,3-dihydroindol-2-one.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06855730B2 |
| 出典データセット | uspto-grants-2005_02 |
| ORD ID | ord-6971769eafbc44aa928743994cee0fcd |
| 出典メモ | uspto-grants-2005_02 |