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Piperidine → 5-acetyl-3-(3-methyl-1H-indol-2-ylmethylene)-1,3-dihydro-indol-2-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Piperidine | HCID 8082 | — |
| 反応物 | 3-Methyl-1H-indole-2-carbaldehyde | HCID 277260 | — |
| 反応物 | 5-acetyl-2,3-dihydro-1H-indol-2-one | HCID 10219643 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 5-acetyl-3-(3-methyl-1H-indol-2-ylmethylene)-1,3-dihydro-indol-2-one | HCID 53819303 | 75% |
反応手順
A mixture of 5-acetyl-2-oxindole (70 mg), 3-methylindole-2-carbaldehyde (56 mg) (prepared according to Synthetic Communications, 1986, 16, 1799) and piperidine (30 mg) in ethanol (1 mL) was held in a sealed tube at 90° C. overnight. The mixture was cooled to room temperature. The solid was collected by vacuum filtration, washed with cold ethanol and dried in a vacuum to give 83 mg (75% yield) of 5-acetyl-3-(3-methyl-1H-indol-2-ylmethylene)-1,3-dihydro-indol-2-one.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06855730B2 |
| 出典データセット | uspto-grants-2005_02 |
| ORD ID | ord-0d1f5f5413b047e993118d1e8df8d3b2 |
| 出典メモ | uspto-grants-2005_02 |