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Piperidine → 5-chloro-3-(1H-indol-2-ylmethylene)-1,3-dihydroindol-2-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Piperidine | HCID 8082 | — |
| 反応物 | Indole-2-carboxaldehyde | HCID 96389 | — |
| 反応物 | 5-Chlorooxindole | HCID 152801 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 5-chloro-3-(1H-indol-2-ylmethylene)-1,3-dihydroindol-2-one | HCID 54258335 | — |
反応手順
A mixture of 5-chloro-2-oxindole (167 mg), indole-2-carbaldehyde (174 mg) (prepared according to Synthetic Communications, 1993, 23, 3109) and piperidine (10 mg) in ethanol was held in a sealed tube at 95° C. for 4 hours. The mixture was cooled to room temperature. The solid was collected by vacuum filtration, washed with cold ethanol and dried in a vacuum oven to give 5-chloro-3-(1H-indol-2-ylmethylene)-1,3-dihydroindol-2-one.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06855730B2 |
| 出典データセット | uspto-grants-2005_02 |
| ORD ID | ord-4189116065504432a1aad00dded1bc97 |
| 出典メモ | uspto-grants-2005_02 |