Ethanol → Ethyl 2-(4-hexylphenyl)acetate

HRID 244933ノート

反応式

HRID 244933 の反応式
[CH2:1]([C:7]1[CH:12]=[CH:11][C:10]([CH2:13][C:14]([OH:16])=[O:15])=[CH:9][CH:8]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH3:6].S(=O)(=O)(O)O.[CH2:22](O)[CH3:23]>>[CH2:1]([C:7]1[CH:8]=[CH:9][C:10]([CH2:13][C:14]([O:16][CH2:22][CH3:23])=[O:15])=[CH:11][CH:12]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH3:6]

参加物

4

反応物 3

HCID 702EthanolHCID 1118Sulfuric AcidHCID 20634302-(4-Hexylphenyl)acetic acid

生成物 1

HCID 3703215Ethyl 2-(4-hexylphenyl)acetate

反応条件

温度
60 °C

実験手順

5.5 g (25 mmol) of 2-(4-hexylphenyl)acetic acid was dissolved in 11 mL of ethanol and mixed with 1.1 g (11.2 mmol) of sulfuric acid and stirred at 60° C. for 1 hour. The reaction was quenched with cold saturated aqueous sodium carbonate (100 ml), and the reaction solution was extracted with ethyl acetate. The organic layer was dried over anhydrous magnesium sulfate and filtered, and the filtrate was concentrated under reduced pressure to give 5.68 g of the desired product as a pale yellow oil.

後処理

  1. customThe reaction was quenched with cold saturated aqueous sodium carbonate (100 ml)
  2. extractionthe reaction solution was extracted with ethyl acetate
  3. dry with materialThe organic layer was dried over anhydrous magnesium sulfate
  4. filtrationfiltered
  5. concentrationthe filtrate was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-1106d78e57ec404380b319f778b70f45
出典データセット
uspto-grants-2014_02
特許番号
US08658686B2

反応ノート

読み込み中…