Piperidine → 3-(3-methyl-1H-indol-2-ylmethylene)-1,3-dihydroindole-2-one

HRID 24494

反応式

HRID 24494 の反応式
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][C:2]1=[O:10].[CH3:11][C:12]1[C:20]2[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=2)[NH:14][C:13]=1[CH:21]=O.N1CCCCC1>C(O)C>[CH3:11][C:12]1[C:20]2[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=2)[NH:14][C:13]=1[CH:21]=[C:3]1[C:4]2[C:9](=[CH:8][CH:7]=[CH:6][CH:5]=2)[NH:1][C:2]1=[O:10]

参加物

5

反応物 3

HCID 8082PiperidineHCID 2772603-Methyl-1H-indole-2-carbaldehydeHCID 321710Oxindole

生成物 1

HCID 541607253-(3-methyl-1H-indol-2-ylmethylene)-1,3-dihydroindole-2-one

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A mixture of 2-oxindole (133 mg), 3-methylindole-2-carbaldehyde (190 mg) (prepared according to Synthetic Communications, 1986, 16, 1799) and piperidine (10 mg) in ethanol was held in a sealed tube at 95° C. for 4 hours. The mixture was cooled to room temperature. The solid was collected by vacuum filtration, washed with cold ethanol and dried in a vacuum oven to give 3-(3-methyl-1H-indol-2-ylmethylene)-1,3-dihydroindole-2-one.

後処理

  1. filtrationThe solid was collected by vacuum filtration
  2. washwashed with cold ethanol
  3. customdried in a vacuum oven

出典と根拠

ORDレコード
ord-d008e4a25a0f41618e2f339428d329a6
出典データセット
uspto-grants-2005_02
特許番号
US06855730B2

関連ノート

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