反応式
[CH:1]([C:3]1[NH:4][C:5]2[CH2:6][CH2:7][CH2:8][CH2:9][C:10]=2[C:11]=1[CH2:12][CH2:13][C:14]([OH:16])=[O:15])=O.[CH3:17][C:18]1[CH:19]=[C:20]2[C:24](=[CH:25][CH:26]=1)[NH:23][C:22](=[O:27])[CH2:21]2.N1CCCCC1.C(O)(=O)C>C(O)C>[CH3:17][C:18]1[CH:19]=[C:20]2[C:24](=[CH:25][CH:26]=1)[NH:23][C:22](=[O:27])[C:21]2=[CH:1][C:3]1[NH:4][C:5]2[CH2:6][CH2:7][CH2:8][CH2:9][C:10]=2[C:11]=1[CH2:12][CH2:13][C:14]([OH:16])=[O:15]参加物
6
反応物 4
生成物 1
試薬・触媒・溶媒 1
実験手順
A mixture of 3-(2-formyl-4,5,6,7-tetrahydro-1H-indol-3-yl)-propionic acid (5.4 g), 3.2 g of 5-methyl-2-oxindole and 2.7 g of piperidine in 25 mL of ethanol was refluxed for 4 hours. Upon addition of acetic acid (8 mL), a precipitate formed. The mixture was refluxed for 5 minutes and cooled to ambient temperature. The precipitate was collected by vacuum filtration and washed with 20 mL of ethanol. The solids were slurry-washed with 30 mL of refluxing ethanol, cooled, collected by vacuum filtration, washed with 30 mL of ethanol and vacuum dried to give 6.2 g (80% yield) of 3-[2-(5-methyl-2-oxo-1,2-dihydroindol-3-ylidenemethyl)-4,5,6,7-tetrahydro-1H-indol-3-yl]-propionic acid as an orange solid.
後処理
- temperaturewas refluxed for 4 hours
- customa precipitate formed
- temperatureThe mixture was refluxed for 5 minutes
- filtrationThe precipitate was collected by vacuum filtration
- washwashed with 20 mL of ethanol
- washThe solids were slurry-washed with 30 mL of refluxing ethanol
- temperaturecooled
- filtrationcollected by vacuum filtration
- washwashed with 30 mL of ethanol and vacuum
- customdried
出典と根拠
- ORDレコード
- ord-a3cc19c140974049b06cace0ee2b617a
- 出典データセット
- uspto-grants-2005_02
- 特許番号
- US06855730B2
関連ノート
読み込み中…