Hydrochloric Acid → 2-Amino-1-methylcyclopentanol hydrochloride

HRID 245053ノート

反応式

HRID 245053 の反応式
C(OC(=O)[NH:7][CH:8]1[CH2:12][CH2:11][CH2:10][C:9]1([OH:14])[CH3:13])(C)(C)C.[ClH:16].O1CCOCC1>ClCCl>[ClH:16].[NH2:7][CH:8]1[CH2:12][CH2:11][CH2:10][C:9]1([CH3:13])[OH:14]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 59281702Tert-butyl 2-hydroxy-2-methylcyclopentylcarbamate

生成物 1

HCID 198184232-Amino-1-methylcyclopentanol hydrochloride

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a solution of tert-butyl-2-hydroxy-2-methyl-cyclopentylcarbamate (25 g, 104.5 mmol) in dichloromethane (210 mL) is added hydrogen chloride in dioxane (156 mL, 6 mol, 4 M) and the reaction is stirred at room temperature for 3 h. The solvent is evaporated and the resulting material is dried under vacuum to a constant weight to obtain the title compound (20.4 g) as a dark brown oil which is used in the next step without further purification. GC-MS 115.1 (M+); GC-MS analysis shows a cis/trans mixture in about a 3/2 ratio.

後処理

  1. customThe solvent is evaporated
  2. customthe resulting material is dried under vacuum to a constant weight

出典と根拠

ORDレコード
ord-8075c701f3d74711af9e5f3bab344e1e
出典データセット
uspto-grants-2014_02
特許番号
US08658693B2

反応ノート

読み込み中…