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1-Methyl-2-imidazolecarboxaldehyde → 5-({[tert-butyl(diphenyl)silyl]oxy}methyl-3-chloro-4-[(2R,6S)-2,6-dimethylmorpholin-4-yl]-2-fluorophenyl}(1-methyl-1H-imidazol-2-yl)methanol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-Methyl-2-imidazolecarboxaldehyde | HCID 139575 | — |
| 反応物 | (2R,6S)-[6-({[tert-butyl(diphenyl)silyl]oxy}methyl)-2-chloro-3-fluorophenyl]-2,6-dimethylmorpholine | HCID 67359669 | — |
| 反応物 | Butyllithium | HCID 178418339 | — |
| 生成物 | 5-({[tert-butyl(diphenyl)silyl]oxy}methyl-3-chloro-4-[(2R,6S)-2,6-dimethylmorpholin-4-yl]-2-fluorophenyl}(1-methyl-1H-imidazol-2-yl)methanol | HCID 131731210 | — |
反応手順
Starting material: (2R,6S)-4-[6-({[tert-butyl(diphenyl)silyl]oxy}methyl)-2-chloro-3-fluorophenyl]-2,6-dimethylmorpholine (Intermediate 42), 1-methyl-imidazole-2-carbaldehyde and n-BuLi
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08658641B2 |
| 出典データセット | uspto-grants-2014_02 |
| ORD ID | ord-85cf89e197624021b342fbdc6e275468 |
| 出典メモ | uspto-grants-2014_02 |