2-Bromo-1,3-thiazole-5-carbaldehyde → (2-bromothiazol-5-yl)(6-((tert-butyldiphenylsilyloxy)methyl)-4-chloro-5-((2R,6S)-2,6-dimethylmorpholino)-3-fluoropyridin-2-yl)methanol

HRID 245400

反応式

HRID 245400 の反応式
[Si:1]([O:18][CH2:19][C:20]1[C:25]([N:26]2[CH2:31][C@H:30]([CH3:32])[O:29][C@H:28]([CH3:33])[CH2:27]2)=[C:24]([Cl:34])[C:23]([F:35])=[CH:22][N:21]=1)([C:14]([CH3:17])([CH3:16])[CH3:15])([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Br:36][C:37]1[S:38][C:39]([CH:42]=[O:43])=[CH:40][N:41]=1>>[Br:36][C:37]1[S:38][C:39]([CH:42]([C:22]2[C:23]([F:35])=[C:24]([Cl:34])[C:25]([N:26]3[CH2:31][C@H:30]([CH3:32])[O:29][C@H:28]([CH3:33])[CH2:27]3)=[C:20]([CH2:19][O:18][Si:1]([C:14]([CH3:17])([CH3:15])[CH3:16])([C:8]3[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=3)[C:2]3[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=3)[N:21]=2)[OH:43])=[CH:40][N:41]=1

参加物

3

反応物 2

HCID 27732592-Bromo-1,3-thiazole-5-carbaldehydeHCID 67319975(2R,6S)-4-(2-((tert-Butyldiphenylsilyloxy)methyl)-4-chloro-5-fluoropyridin-3-yl)-2,6-dimethylmorpholine2 回

生成物 1

HCID 67358161(2-bromothiazol-5-yl)(6-((tert-butyldiphenylsilyloxy)methyl)-4-chloro-5-((2R,6S)-2,6-dimethylmorpholino)-3-fluoropyridin-2-yl)methanol

実験手順

Starting materials: 2R,6S)-4-(2-((tert-butyldiphenylsilyloxy)methyl)-4-chloro-5-fluoropyridin-3-yl)-2,6-dimethylmorpholine (Intermediate 45) and 2-bromothiazole-5-carbaldehyde.

出典と根拠

ORDレコード
ord-443bf41d75fd455f806459a968d512a8
出典データセット
uspto-grants-2014_02
特許番号
US08658641B2

関連ノート

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