反応式
Cl[CH2:2][C:3]1[CH:19]=[CH:18][C:6]([C:7]([NH:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=2[O:16][CH3:17])=[O:8])=[CH:5][CH:4]=1.[CH3:20][NH2:21]>O1CCOCC1>[CH3:17][O:16][C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=1[NH:9][C:7](=[O:8])[C:6]1[CH:18]=[CH:19][C:3]([CH2:2][NH:21][CH3:20])=[CH:4][CH:5]=1参加物
4
実験手順
4-Chloromethyl-N-(2-methoxyphenyl)benzamide (400 mg, 1.45 mmol) was dissolved in dioxane (4 ml) and then mixed with 50% methylamine aqueous solution (4 ml) at room temperature. After 1 hour of stirring at the same temperature, dioxane was removed by evaporation, and the resulting residue was diluted with methylene chloride (10 ml). After drying on anhydrous sodium carbonate, the solvent was removed by evaporation to obtain 500 mg (100%) of the title compound in the form of colorless oil.
後処理
- customwas removed by evaporation
- additionthe resulting residue was diluted with methylene chloride (10 ml)
- dry with materialAfter drying on anhydrous sodium carbonate
- customthe solvent was removed by evaporation
出典と根拠
- ORDレコード
- ord-1e483b3adf244fe28b89df6ce80d81bc
- 出典データセット
- uspto-grants-1998_03
- 特許番号
- US05728835
関連ノート
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