Propylene Oxide → HCID 67358844、化合物
反応式
[CH2:1]([NH:8][CH2:9][CH:10]([OH:13])[CH2:11][CH3:12])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:14]1[O:17][CH:15]1[CH3:16]>C(O)C>[CH2:1]([N:8]([CH2:14][CH:15]([OH:17])[CH3:16])[CH2:9][CH:10]([OH:13])[CH2:11][CH3:12])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1参加物
4
反応条件
- 温度
- 150 °C
実験手順
To a solution of 1-benzylamino-butan-2-ol (Intermediate 482, 8.5 g, 47.48 mmol) in ethanol (150 mL) was added propylene oxide (8.8 g, 151 mmole) and the mixture was heated at 150° C. for 2 h in autoclave. After concentration of the mixture under reduced pressure, the residue was purified by column chromatography using methanol in dichloromethane to give product as an oil. Yield: 10.2 g (93%).
後処理
- customAfter concentration of the mixture under reduced pressure, the residue was purified by column chromatography
- customto give product as an oil
出典と根拠
- ORDレコード
- ord-8e7ad322f2ad4740b4229c596abdf740
- 出典データセット
- uspto-grants-2014_02
- 特許番号
- US08658641B2
反応ノート
読み込み中…