Hydrochloric Acid → HCID 178432911、化合物
反応式
[Br:1][C:2]1[N:3]=[C:4]([C@H:12]2[CH2:17][CH2:16][C@H:15]([N:18]3[CH2:23][CH2:22][N:21](C(=O)C)[CH2:20][CH2:19]3)[CH2:14][CH2:13]2)[N:5]2[CH:10]=[CH:9][N:8]=[C:7]([CH3:11])[C:6]=12.[ClH:27]>C(O)C>[ClH:27].[Br:1][C:2]1[N:3]=[C:4]([C@H:12]2[CH2:13][CH2:14][C@H:15]([N:18]3[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]3)[CH2:16][CH2:17]2)[N:5]2[CH:10]=[CH:9][N:8]=[C:7]([CH3:11])[C:6]=12参加物
4
実験手順
To 1-(4-((trans)-4-(1-bromo-8-methylimidazo[1,5-a]pyrazin-3-yl)cyclohexyl)piperazin-1-yl)ethanone (0.108 mmol, 45.4 mg) in ethanol was added 2 M hydrochloric acid (4.32 mmol, 2.16 ml) and stirred at reflux for four hours. The reaction mixture was cooled, concentrated in vacuo, coevaporated with toluene twice and washed with dichloromethane twice to give 1-bromo-8-methyl-3-((trans)-4-(piperazin-1-yl)cyclohexyl)imidazo[1,5-a]pyrazine hydrochloride (56 mg) product which was used without further purification.