Hydrochloric Acid → 1-Oxazol-4-yl-ethylamine dihydrochloride

HRID 245900ノート

反応式

HRID 245900 の反応式
[O:1]1[CH:5]=[C:4]([CH:6]([NH:8]S(C(C)(C)C)=O)[CH3:7])[N:3]=[CH:2]1.[ClH:15]>CO>[ClH:15].[ClH:15].[O:1]1[CH:5]=[C:4]([CH:6]([NH2:8])[CH3:7])[N:3]=[CH:2]1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 712881692-Methyl-N-[1-(4-oxazolyl)ethyl]-2-propanesulfinamide

生成物 1

HCID 866779161-Oxazol-4-yl-ethylamine dihydrochloride

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

In a round-bottomed flask, 2-methyl-propane-2-sulfinic acid (1-oxazol-4-yl-ethyl)-amide (585 mg, 2.57 mmol) was dissolved in methanol (4.5 ml) and hydrogen chloride (4.0 M in 1,4-dioxane, 1.3 ml, 5.2 mmol) was added dropwise. The reaction mixture was stirred at room temperature for 15 min then concentrated to give 1-oxazol-4-yl-ethylamine dihydrochloride as a viscous orange oil which was used without further purification.

後処理

  1. concentrationthen concentrated

出典と根拠

ORDレコード
ord-50b918b7204642d3a4314842968e8a3e
出典データセット
uspto-grants-2014_02
特許番号
US08658646B2

反応ノート

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