Hydrochloric Acid → 1-(1,2-Oxazol-3-yl)ethan-1-amine hydrochloride

HRID 245905ノート

反応式

HRID 245905 の反応式
[O:1]1[CH:5]=[CH:4][C:3]([CH:6]([NH:8]S(C(C)(C)C)=O)[CH3:7])=[N:2]1.[ClH:15]>CO>[ClH:15].[O:1]1[CH:5]=[CH:4][C:3]([CH:6]([NH2:8])[CH3:7])=[N:2]1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 71288179N-[1-(3-Isoxazolyl)ethyl]-2-methyl-2-propanesulfinamide

生成物 1

HCID 552533511-(1,2-Oxazol-3-yl)ethan-1-amine hydrochloride

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

In a round-bottomed flask, 2-methyl-propane-2-sulfinic acid (1-isoxazol-3-yl-ethyl)-amide (652 mg, 2.71 mmol) was dissolved in methanol (5 ml) and hydrogen chloride (4.0 M in 1,4-dioxane, 1.4 ml, 5.6 mmol) was added dropwise. The reaction mixture was stirred at room temperature for 15 min then concentrated to give 1-isoxazol-3-yl-ethylamine hydrochloride as an off-white solid which was used without further purification.

後処理

  1. concentrationthen concentrated

出典と根拠

ORDレコード
ord-d28636f012234258acc27013aad70633
出典データセット
uspto-grants-2014_02
特許番号
US08658646B2

反応ノート

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