関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Benzylamine | HCID 7504 | — |
| 反応物 | 6-Bromo-3,4-dihydro-2H-isoquinolin-1-one | HCID 21865450 | — |
| 試薬 | Sodium Methoxide | HCID 10942334 | — |
| 触媒 | 1,2-Bis(diphenylphosphino)ethane | HCID 74267 | — |
| 触媒 | Palladium (II) acetate | HCID 4144353 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | 6-benzylamino-3,4-dihydro-2H-isoquinolin-1-one | HCID 67223915 | 0% |
反応手順
In a small MW* sealed test tube was 6-bromo-3,4-dihydroisoquinolin-1(2H)-one (50 mg, 0.22 mmol), phenylmethanamine (24.16 µl, 0.22 mmol), palladium(II) acetate (2.483 mg, 0.01 mmol), Ethylenebis(diphenylphosphine) (8.81 mg, 0.02 mmol) and sodium methoxide (13.14 mg, 0.24 mmol) in toluene (2188 µl) combined to give a orange suspension. Heated reaction to 100°C overnight. Took LCMS - No reaction, only see unreacted SM. Discarded reaction.
情報源と証拠
| 出典データセット | 750 AstraZeneca ELN dataset |
|---|
| ORD ID | ord-08bf18171af14ad9bb3d94faf7cd7b73 |
|---|
| 出典メモ | 750 AstraZeneca ELN dataset |
|---|
