Triethylamine → 1-(2,2-Diethoxyethyl)-4-(4-fluorobenzoyl)piperidine

HRID 2460

反応式

HRID 2460 の反応式
[F:1][C:2]1[CH:15]=[CH:14][C:5]([C:6]([CH:8]2[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]2)=[O:7])=[CH:4][CH:3]=1.[CH2:16]([O:18][CH:19]([O:22][CH2:23][CH3:24])[CH2:20]Br)[CH3:17].C(N(CC)CC)C>C(Cl)Cl>[CH2:16]([O:18][CH:19]([O:22][CH2:23][CH3:24])[CH2:20][N:11]1[CH2:12][CH2:13][CH:8]([C:6](=[O:7])[C:5]2[CH:4]=[CH:3][C:2]([F:1])=[CH:15][CH:14]=2)[CH2:9][CH2:10]1)[CH3:17]

参加物

5

反応物 3

HCID 8471TriethylamineHCID 74852Ethane, 2-bromo-1,1-diethoxy-HCID 27244404-(4-Fluorobenzoyl)piperidine

生成物 1

HCID 196900081-(2,2-Diethoxyethyl)-4-(4-fluorobenzoyl)piperidine収率 25%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

4-(4-Fluorobenzoyl)piperidine (207 mg, 1.0 mmol) was dissolved in methylene chloride (5 ml) to which were subsequently added bromoacetoaldehyde diethylacetal (305 mg, 1.5 mmol) and triethylamine (0.5 ml). After 12 hours of heating under reflux, the solvent was removed by evaporation, and the resulting residue was purified by subjecting it to a silica gel column chromatography (ether) to obtain 81 mg (25.0%) of the title compound in the form of orange oil.

後処理

  1. temperatureAfter 12 hours of heating
  2. temperatureunder reflux
  3. customthe solvent was removed by evaporation
  4. customthe resulting residue was purified

出典と根拠

ORDレコード
ord-3ff4585334ae4e29b75a677785e6dfac
出典データセット
uspto-grants-1998_03
特許番号
US05728835

関連ノート

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