Hydrochloric Acid → 1-((R)-1-amino-ethyl)-cyclopentanecarbonitrile hydrochloride
反応式
[C:1]([C:3]1([C@H:8]([NH:10][S@](C(C)(C)C)=O)[CH3:9])[CH2:7][CH2:6][CH2:5][CH2:4]1)#[N:2].[ClH:17]>CO>[ClH:17].[NH2:10][C@@H:8]([C:3]1([C:1]#[N:2])[CH2:7][CH2:6][CH2:5][CH2:4]1)[CH3:9]参加物
4
実験手順
(S)-2-Methyl-propane-2-sulfinic acid [(R)-1-(1-cyano-cyclopentyl)-ethyl]-amide (1.96 g, 8.07 mmol) was dissolved in MeOH (16 mL) and HCl (4.0 M in 1,4-dioxane, 4.0 mL, 16.0 mmol) was added. The reaction mixture was stirred at room temperature for 30 min then concentrated to give 1-((R)-1-amino-ethyl)-cyclopentanecarbonitrile hydrochloride as an off-white solid which was used without further purification.
後処理
- concentrationthen concentrated
出典と根拠
- ORDレコード
- ord-3cbf63dcce604c9592cc755ccf4c49a6
- 出典データセット
- uspto-grants-2014_02
- 特許番号
- US08658646B2
反応ノート
読み込み中…