Hydrochloric Acid → (S)-1-(5-(trifluoromethyl)-1H-imidazol-2-yl)ethanamine hydrochloride

HRID 246552ノート

反応式

HRID 246552 の反応式
C(OC(=O)[NH:7][C@H:8]([C:10]1[NH:11][C:12]([C:15]([F:18])([F:17])[F:16])=[CH:13][N:14]=1)[CH3:9])(C)(C)C.[ClH:20]>O1CCOCC1>[ClH:20].[F:18][C:15]([F:16])([F:17])[C:12]1[NH:11][C:10]([C@@H:8]([NH2:7])[CH3:9])=[N:14][CH:13]=1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 71280415(S)-tert-butyl 1-(5-(trifluoromethyl)-1H-imidazol-2-yl)ethylcarbamate

生成物 1

HCID 71279885(S)-1-(5-(trifluoromethyl)-1H-imidazol-2-yl)ethanamine hydrochloride

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

A solution of [(S)-1-(5-trifluoromethyl-1H-imidazol-2-yl)-ethyl]-carbamic acid tert-butyl ester (50 mg, 179 μmol) in 4M HCl in dioxane (2 mL) was stirred at room temperature for 15 h. The mixture was concentrated in vacuo then triturated with ether to give (S)-1-(5-trifluoromethyl-1H-imidazol-2-yl)-ethylamine hydrochloride (35 mg, quantitative) as a yellow oil. LCMS, [M+H]=180.

後処理

  1. concentrationThe mixture was concentrated in vacuo
  2. customthen triturated with ether

出典と根拠

ORDレコード
ord-88c914026c9440bfbb921eb358b02c00
出典データセット
uspto-grants-2014_02
特許番号
US08658646B2

反応ノート

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