関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | Chloromethyl pivalate | HCID 87885 | — |
| 反応物 | 1H-Indazole-4-boronic acid | HCID 44118310 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | (1-((Pivaloyloxy)methyl)-1H-indazol-4-yl)boronic acid | HCID 71279678 | — |
反応手順
A mixture of 1H-indazol-4-ylboronic acid (0.2 g, 1.227 mmol), chloromethyl pivalate (554 mg, 3.68 mmol) and K2CO3 (509 mg, 3.68 mmol) in dry DMF (10 mL) was heated to 30° C. for 16 hours. Reaction was quenched with water and product extracted with ethyl acetate (150 mL), then washed with water (3×20 mL) and brine (2×20 mL), then dried over Na2SO4, filtered and concentrated. The product (114 mg, crude) was obtained and used into next step without further purification. LCMS: (M+Na)+=299.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08658646B2 |
|---|
| 出典データセット | uspto-grants-2014_02 |
|---|
| ORD ID | ord-59ea6838107e4f3a887081ff9ccff2ef |
|---|
| 出典メモ | uspto-grants-2014_02 |
|---|
