Sulfuric Acid → Benzylsulfamic acid

HRID 246829ノート

反応式

HRID 246829 の反応式
[CH2:1]([N:8]=C=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[S:11](=O)(=[O:14])([OH:13])[OH:12]>[N+](C)([O-])=O>[CH2:1]([NH:8][S:11](=[O:13])(=[O:12])[OH:14])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

4

反応物 2

HCID 1118Sulfuric AcidHCID 76639Benzyl isocyanate

生成物 1

HCID 12649342Benzylsulfamic acid

試薬・触媒・溶媒 1

HCID 6375Nitromethane溶媒

実験手順

Benzylisocyanate (13.3 g) is added dropwise to a stirred mixture of nitromethane (160 ml) and 15% fuming sulfuric acid (5.4 ml) at about 10° C. The reaction mixture is refluxed for about one hour, cooled to RT and the solid filtered and washed with nitromethane. The solid is suspended in ether, filtered, dried and used as a crude solid in the next step.

後処理

  1. temperatureThe reaction mixture is refluxed for about one hour
  2. filtrationthe solid filtered
  3. washwashed with nitromethane
  4. filtrationfiltered
  5. customdried

出典と根拠

ORDレコード
ord-a2a22afeb7bc47b199b85f68f22f7a67
出典データセット
uspto-grants-1987_11
特許番号
US04704388

反応ノート

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