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Thiomorpholine → 4-(3,5-Dimethoxybenzyl)thiomorpholine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Thiomorpholine | HCID 67164 | — |
| 反応物 | 3,5-Dimethoxybenzyl chloride | HCID 2758395 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 4-(3,5-Dimethoxybenzyl)thiomorpholine | HCID 756021 | 73.7% |
反応手順
Thiomorpholine (3.4 g) was added to a solution of 3,5-dimethoxybenzyl chloride (2 g) in THF (25 mL) and the mixture was stirred overnight at room temperature. The solid material was removed by filtration and the filtrate was evaporated. The residue was purified by column chromatography (silica gel; eluent: EtOAc/hexane 1/2) to yield 2 g of 3,5-dimethoxy-1-(thiomorpholino-methyl)benzene. ESMS: m/z 253 (M).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06855843B2 |
| 出典データセット | uspto-grants-2005_02 |
| ORD ID | ord-d8bd3fe4ea95445aa9547aebb5a6afed |
| 出典メモ | uspto-grants-2005_02 |