Bromochloromethane → 4-(Chloromethylthio) benzyl alcohol

HRID 247064

反応式

HRID 247064 の反応式
[SH:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6][OH:7])=[CH:4][CH:3]=1.Br[CH2:11][Cl:12].C(N(CC)CC)C>>[Cl:12][CH2:11][S:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6][OH:7])=[CH:4][CH:3]=1

参加物

4

反応物 3

HCID 6333BromochloromethaneHCID 8471TriethylamineHCID 4677905(4-Sulfanylphenyl)methanol

生成物 1

HCID 538676354-(Chloromethylthio) benzyl alcohol

実験手順

4-Mercaptobenzyl alcohol (see J.Chem.Soc 1963 p 1947) (5.0 mmol) was dissolved in bromochloromethane (100 mmol) and triethylamine (5 mmol) added dropwise. The resultant mixture was stirred for 1 hour at room temperature, washed with water and the dried (MgSO4) organic solution evaporated to leave the product. Yield 0.94g (95%) 1H NMR (CDCl3, δ): 2.03 (OH), 4.65 (CH2O), 4.90 (CH2S), 7.1-7.4 (Ph). The product needed no further purification for use in Example 33.

後処理

  1. washwashed with water
  2. dry with materialthe dried (MgSO4) organic solution
  3. customevaporated
  4. customto leave the product
  5. customno further purification for use in Example 33

出典と根拠

ORDレコード
ord-0b078959122b4c1ead27ab20e7cc57cb
出典データセット
uspto-grants-1987_11
特許番号
US04705791

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