Hydrochloric Acid → 2-(2,6-Dimethoxyphenyl)ethanol

HRID 24707

反応式

HRID 24707 の反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5](CC(O)=O)[CH:6]=[C:7]([O:9][CH3:10])[CH:8]=1.[H-].[H-].[H-].[H-].[Li+].[Al+3].Cl.[CH3:22][CH2:23][O:24]CC>>[CH3:10][O:9][C:7]1[CH:6]=[CH:5][CH:4]=[C:3]([O:2][CH3:1])[C:8]=1[CH2:22][CH2:23][OH:24]

参加物

5

反応物 4

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 138316(3,5-Dimethoxyphenyl)acetic acidHCID 21226445Aluminium lithium hydride

生成物 1

HCID 2656332-(2,6-Dimethoxyphenyl)ethanol

実験手順

A solution of (3,5-dimethoxy)phenylacetic acid (3 g) in Et2O (100 mL) was cooled to 0° C. and LiAlH4 (1M in Et2O, 16.8 mL) was added. The mixture was warmed to room temperature and stirred for 5 h, whereupon the pH was adjusted to 5 using HCl (1 M). The mixture was washed with H2O/EtOAc and the organic layer was separated. The aqueous layer was extracted with EtOAc. The combined organic layers were dried (MgSO4) and concentrated in vacuo to give 3,5-dimethoxy-4-(2-hydroxyethyl)benzene (2.8 g) as a crude product.

後処理

  1. washThe mixture was washed with H2O/EtOAc
  2. customthe organic layer was separated
  3. extractionThe aqueous layer was extracted with EtOAc
  4. dry with materialThe combined organic layers were dried (MgSO4)
  5. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-ae5a074dd2d144a895c715f5decbdd0e
出典データセット
uspto-grants-2005_02
特許番号
US06855843B2

関連ノート

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