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Imidazole → 3,5-Dimethoxybenzyl tert-butyldiphenylsilyl ether
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Imidazole | HCID 795 | — |
| 反応物 | 3,5-Dimethoxybenzyl alcohol | HCID 69718 | — |
| 反応物 | tert-Butyldiphenylchlorosilane | HCID 94078 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 3,5-Dimethoxybenzyl tert-butyldiphenylsilyl ether | HCID 22571883 | 87.9% |
反応手順
A mixture of 3,5-dimethoxybenzyl alcohol (4.0 g), tert-butyl-diphenylsilyl chloride (6.54 g) and imidazole (3.28 g) in DMF (60 mL) was stirred at room temperature for 24 h. DMF was evaporated and the residue was purified by column chromatography (silica gel; eluent: hexane to hexane/EtOAc 20% ) to yield 8.5 g of 3,5-dimethoxybenzyl tert-butyldiphenylsilyl ether. ESMS: m/z 407 (MH+).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06855843B2 |
| 出典データセット | uspto-grants-2005_02 |
| ORD ID | ord-5a5ba54c17ac44b8bce09720bb95188c |
| 出典メモ | uspto-grants-2005_02 |