1-(Cyanomethyl)-3,5-dimethoxybenzene → 1-Bromo-2,4-dimethoxy-6-cyanobenzene

HRID 24709ノート

反応式

HRID 24709 の反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:8]=[C:9]([O:11][CH3:12])[CH:10]=1)[C:6]#[N:7].[Br-:13].[Br-].[Br-].[NH+]1C=CC=CC=1.[NH+]1C=CC=CC=1.[NH+]1C=CC=CC=1>C(Cl)Cl>[Br:13][C:4]1[C:5]([C:6]#[N:7])=[CH:8][C:9]([O:11][CH3:12])=[CH:10][C:3]=1[O:2][CH3:1]

参加物

4

反応物 2

HCID 294821-(Cyanomethyl)-3,5-dimethoxybenzeneHCID 21124087Pyridiniumtribromide

生成物 1

HCID 225718291-Bromo-2,4-dimethoxy-6-cyanobenzene収率 89.2%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a solution of 3,5-dimethoxybenzonitrile (2 g) in CH2Cl2 (100 mL) was added pyridinium tribromide (4 g). The mixture was stirred for 24 h at room temperature then washed successively with aqueous NaHCO3, water and brine, dried (MgSO4) filtered and evaporated. The residue was crystallized from CH2Cl2 and hexane to yield the title compound (1.8 g).

後処理

  1. washthen washed successively with aqueous NaHCO3, water and brine
  2. dry with materialdried (MgSO4)
  3. filtrationfiltered
  4. customevaporated
  5. customThe residue was crystallized from CH2Cl2 and hexane

出典と根拠

ORDレコード
ord-27cbedddaa434946b43587b7aee9fe3e
出典データセット
uspto-grants-2005_02
特許番号
US06855843B2

反応ノート

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