化工社化工社 化学情報印刷レポート · 研究参考用
Sodium hydride → 6-[5-(4-Chlorobenzyl)-thien-2-yl]-hex-5-enoic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium hydride | HCID 24758 | — |
| 反応物 | (4-Carboxybutyl)triphenylphosphonium bromide | HCID 161236 | — |
| 反応物 | 5-(4-Chlorobenzyl)thiophene-2-carbaldehyde | HCID 20161500 | — |
| 溶媒 | Dimethyl Sulfoxide | HCID 679 | — |
| 生成物 | 6-[5-(4-Chlorobenzyl)-thien-2-yl]-hex-5-enoic acid | HCID 54182590 | — |
反応手順
This compound is prepared analogously to Example 7b from: 6.3 g of sodium hydride (=7.8 g of 80% strength mineral oil suspension) in 180 ml of dimethylsulphoxide, 57.9 g of 4-hydroxycarbonylbutyl-triphenylphosphonium bromide in 180 ml of dimethylsulphoxide and 25.0 g of 5-(4-chlorobenzyl)-thiophene-2-aldehyde in 20 ml of dimethylsulphoxide.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04705802 |
| 出典データセット | uspto-grants-1987_11 |
| ORD ID | ord-37d47b237a01413e978b2383e470b0ce |
| 出典メモ | uspto-grants-1987_11 |