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3-Nitrobenzaldehyde → 5-Acetyl-1,4-dihydro-2,6-dimethyl-3-(3-chloromethyl-1,2,4-oxadiazol-5-yl)-4-(3-nitrophenyl)pyridine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-Nitrobenzaldehyde | HCID 7449 | — |
| 反応物 | 4-Amino-3-penten-2-one | HCID 136873 | — |
| 反応物 | 5-Acetonyl-3-chloromethyl-1,2,4-oxadiazole | HCID 13824705 | — |
| 溶媒 | Isopropanol | HCID 3776 | — |
| 生成物 | 5-Acetyl-1,4-dihydro-2,6-dimethyl-3-(3-chloromethyl-1,2,4-oxadiazol-5-yl)-4-(3-nitrophenyl)pyridine | HCID 135833423 | 67.1% |
反応手順
A stirred solution of 0.53 g of 5-acetonyl-3-chloromethyl-1,2,4-oxadiazole, 0.46 g of 3-nitrobenzaldehyde and 0.30 g of 2-amino-4-oxo-2-pentene in 4 ml of isopropyl alcohol was heated under reflux for 14 hours. The reaction mixture was concentrated in vacuo and the residue was chromatographed on silica gel using benzene-acetonitrile (15:1) as eluent to give 0.79 g of 5-acetyl-1,4-dihydro-2,6-dimethyl-3-(3-chloromethyl-1,2,4-oxadiazol-5-yl)-4-(3-nitrophenyl)pyridine.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04705786 |
| 出典データセット | uspto-grants-1987_11 |
| ORD ID | ord-3a3cdfe57e434f88a507f35d90df3dfe |
| 出典メモ | uspto-grants-1987_11 |