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2-Chloroethyl Isothiocyanate → 2-Chloro-4-(2-thiazolinylamino)benzoic acid methyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Chloroethyl Isothiocyanate | HCID 138661 | — |
| 反応物 | Methyl 4-Amino-2-chlorobenzoate | HCID 11839197 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 2-Chloro-4-(2-thiazolinylamino)benzoic acid methyl ester | HCID 69564628 | — |
反応手順
A mixture of 4-amino-2-chlorobenzoic acid methyl ester (0.5 g) and 2-chloroethylisothiocyanate (0.26 mL) in THF (20 mL) was refluxed for 24 h. THF was distilled and the residue was purified by column chromatography (silica gel: eluent: hexane/EtOAc 3:1-1:1) to yield 2-chloro-4-(2-thiazolinylamino)benzoic acid methyl ester (74 mg). ESMS: m/z 271 (MH+).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06855843B2 |
| 出典データセット | uspto-grants-2005_02 |
| ORD ID | ord-2a25a18e5f0c4c359bac4a1888fb1f0e |
| 出典メモ | uspto-grants-2005_02 |