4-Fluorobenzoic Acid → 4-Fluorobenzoic acid, 3-fluorophenyl ester

HRID 247186

反応式

HRID 247186 の反応式
[F:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[CH:4][CH:3]=1>COCCOCCOCCOCCOC>[F:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([O:8][C:4]2[CH:5]=[CH:9][CH:10]=[C:2]([F:1])[CH:3]=2)=[O:7])=[CH:4][CH:3]=1

参加物

3

反応物 1

HCID 99734-Fluorobenzoic Acid

生成物 1

HCID 141493914-Fluorobenzoic acid, 3-fluorophenyl ester収率 1.1%

試薬・触媒・溶媒 1

HCID 8925Tetraglyme溶媒

反応条件

温度
240 °C

実験手順

A 25-ml Kjeldahl flask fitted with an air-cooling line was charged with 1.4 g of p-flurobenzoic acid, 0.976 g of cupric hydroxide, and 3 ml of tetraglyme as solvent, after which it was heated at 240° C. over an oil bath. This temperature was maintained for 60 minutes. After cooling, the reaction mixture was eluted with diethyl ether followed by filtration using Celite. the resulting filtrate was then submitted to column chromatography (solid phase: silica gel, developing solvent: hexane→methylene chloride) to give 0.013 g of m-fluorophenyl p-fluorobenzoate.

後処理

  1. customA 25-ml Kjeldahl flask fitted with an air-cooling line
  2. temperatureThis temperature was maintained for 60 minutes
  3. temperatureAfter cooling
  4. washthe reaction mixture was eluted with diethyl ether
  5. filtrationfollowed by filtration

出典と根拠

ORDレコード
ord-e7eec9de80b243ba891dc68229b2903d
出典データセット
uspto-grants-1987_11
特許番号
US04705884

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