4-Fluorobenzoic Acid → 4-Fluorobenzoic acid, 3-fluorophenyl ester
反応式
[F:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[CH:4][CH:3]=1>COCCOCCOCCOCCOC>[F:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([O:8][C:4]2[CH:5]=[CH:9][CH:10]=[C:2]([F:1])[CH:3]=2)=[O:7])=[CH:4][CH:3]=1参加物
3
反応条件
- 温度
- 240 °C
実験手順
A 25-ml Kjeldahl flask fitted with an air-cooling line was charged with 1.4 g of p-flurobenzoic acid, 0.976 g of cupric hydroxide, and 3 ml of tetraglyme as solvent, after which it was heated at 240° C. over an oil bath. This temperature was maintained for 60 minutes. After cooling, the reaction mixture was eluted with diethyl ether followed by filtration using Celite. the resulting filtrate was then submitted to column chromatography (solid phase: silica gel, developing solvent: hexane→methylene chloride) to give 0.013 g of m-fluorophenyl p-fluorobenzoate.
後処理
- customA 25-ml Kjeldahl flask fitted with an air-cooling line
- temperatureThis temperature was maintained for 60 minutes
- temperatureAfter cooling
- washthe reaction mixture was eluted with diethyl ether
- filtrationfollowed by filtration
出典と根拠
- ORDレコード
- ord-e7eec9de80b243ba891dc68229b2903d
- 出典データセット
- uspto-grants-1987_11
- 特許番号
- US04705884
反応ノート
読み込み中…