Hydrochloric Acid → 1-(Chloromethyl)-4-Ethoxybenzene

HRID 247243

反応式

HRID 247243 の反応式
[CH2:1]([O:3][C:4]1[CH:11]=[CH:10][C:7]([CH2:8]O)=[CH:6][CH:5]=1)[CH3:2].[ClH:12]>>[CH2:1]([O:3][C:4]1[CH:11]=[CH:10][C:7]([CH2:8][Cl:12])=[CH:6][CH:5]=1)[CH3:2]

参加物

3

反応物 2

HCID 313Hydrochloric AcidHCID 803454-Ethoxybenzyl alcohol

生成物 1

HCID 20639711-(Chloromethyl)-4-Ethoxybenzene

実験手順

4-Ethoxybenzyl alcohol (5 g) and concentrated hydrochloric acid (8.5 cm3) were vigorously stirred together for 30 minutes. The 2 phases were then allowed to separate, and the lower layer separated off, and diluted with chloroform. The organic solution was dried over anhydrous magnesium sulphate, and removal of the solvent by evaporation gave 4-ethoxybenzyl chloride (5.6 g). (This product is not stable on keeping, so was converted immediately to the phosphonium salt--see Example 12).

後処理

  1. customto separate
  2. customthe lower layer separated off
  3. additiondiluted with chloroform
  4. dry with materialThe organic solution was dried over anhydrous magnesium sulphate, and removal of the solvent by evaporation

出典と根拠

ORDレコード
ord-382b06ac20c74a1b8108fdcbcd7ddda9
出典データセット
uspto-grants-1987_11
特許番号
US04705900

関連ノート

読み込み中…