Hydrochloric Acid → 1-(Chloromethyl)-4-Ethoxybenzene
反応式
[CH2:1]([O:3][C:4]1[CH:11]=[CH:10][C:7]([CH2:8]O)=[CH:6][CH:5]=1)[CH3:2].[ClH:12]>>[CH2:1]([O:3][C:4]1[CH:11]=[CH:10][C:7]([CH2:8][Cl:12])=[CH:6][CH:5]=1)[CH3:2]参加物
3
実験手順
4-Ethoxybenzyl alcohol (5 g) and concentrated hydrochloric acid (8.5 cm3) were vigorously stirred together for 30 minutes. The 2 phases were then allowed to separate, and the lower layer separated off, and diluted with chloroform. The organic solution was dried over anhydrous magnesium sulphate, and removal of the solvent by evaporation gave 4-ethoxybenzyl chloride (5.6 g). (This product is not stable on keeping, so was converted immediately to the phosphonium salt--see Example 12).
後処理
- customto separate
- customthe lower layer separated off
- additiondiluted with chloroform
- dry with materialThe organic solution was dried over anhydrous magnesium sulphate, and removal of the solvent by evaporation
出典と根拠
- ORDレコード
- ord-382b06ac20c74a1b8108fdcbcd7ddda9
- 出典データセット
- uspto-grants-1987_11
- 特許番号
- US04705900
反応ノート
読み込み中…