Benzene, (triethoxymethyl)- → 1-Acetyl-3-(1-ethoxy-1-phenylmethylidene}-2-indolinone

HRID 24725

反応式

HRID 24725 の反応式
[C:1]([N:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[CH2:6][C:5]1=[O:13])(=[O:3])[CH3:2].[CH3:14][CH2:15][O:16][C:17](OCC)(OCC)[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>C(OC(=O)C)(=O)C>[C:1]([N:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:6](=[C:17]([O:16][CH2:15][CH3:14])[C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[C:5]1=[O:13])(=[O:3])[CH3:2]

参加物

4

反応物 2

HCID 74268Benzene, (triethoxymethyl)-HCID 3237191-Acetylindolin-2-one

生成物 1

HCID 542378881-Acetyl-3-(1-ethoxy-1-phenylmethylidene}-2-indolinone

試薬・触媒・溶媒 1

HCID 7918Acetic Anhydride溶媒

実験手順

35.0 g (0.2 mol) of 1-acetyl-2-indolinone are dissolved in 300 ml of acetic anhydride and after the addition of 135 g (0.6 mol) of triethyl orthobenzoate the mixture is refluxed for 22 hours. The solvent is distilled off and the residue diluted with petroleum ether. After 18 hours' standing at ambient temperature, the crystalline precipitate is suction filtered, washed and dried.

後処理

  1. temperatureis refluxed for 22 hours
  2. distillationThe solvent is distilled off
  3. additionthe residue diluted with petroleum ether
  4. filtrationfiltered
  5. washwashed
  6. customdried

出典と根拠

ORDレコード
ord-9cad90a0f5794d64b7d4ec75067742a0
出典データセット
uspto-grants-2005_02
特許番号
US06855710B2

関連ノート

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