Ammonia → 5-Hydroxy-6-isoquinolinecarboxamide

HRID 247255ノート

反応式

HRID 247255 の反応式
C[O:2][C:3]([C:5]1[C:6]([OH:15])=[C:7]2[C:12](=[CH:13][CH:14]=1)[CH:11]=[N:10][CH:9]=[CH:8]2)=O.[NH3:16]>>[OH:15][C:6]1[C:5]([C:3]([NH2:16])=[O:2])=[CH:14][CH:13]=[C:12]2[C:7]=1[CH:8]=[CH:9][N:10]=[CH:11]2

参加物

3

反応物 2

HCID 222Ammonia2 回HCID 54242020Methyl 5-hydroxyisoquinoline-6-carboxylate

生成物 1

HCID 185359865-Hydroxy-6-isoquinolinecarboxamide

実験手順

5-Hydroxy-6-isoquinolinecarboxylic acid methyl ester as reported by Dyke, S. F. et al., in Tetrahedron 1973, 29(6), 857-62, is reacted with excess ammonia in a steel bomb for 12-18 hr. The excess ammonia is allowed to evaporate and the residue is crystallized from a suitable solvent mix such as ethyl acetate-toluene to give the title compound.

後処理

  1. customto evaporate
  2. customthe residue is crystallized from a suitable solvent
  3. additionmix such as ethyl acetate-toluene

出典と根拠

ORDレコード
ord-5d402676aa1942e0ac660d4da313793b
出典データセット
uspto-grants-1987_11
特許番号
US04705853

反応ノート

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