Hydrogen chloride-ethyl acetate → HCID 178507732、化合物

HRID 24758

反応式

HRID 24758 の反応式
C(OC([NH:8][C:9]1[CH:14]=[CH:13][C:12]([NH:15]/[C:16](=[C:23]2\[C:24](=[O:32])[NH:25][C:26]3[C:31]\2=[CH:30][CH:29]=[CH:28][CH:27]=3)/[C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)=[CH:11][CH:10]=1)=O)(C)(C)C.C(OCC)(=O)C.Cl>ClCCl.CCOCC>[NH2:8][C:9]1[CH:14]=[CH:13][C:12]([NH:15]/[C:16](=[C:23]2\[C:24](=[O:32])[NH:25][C:26]3[C:31]\2=[CH:30][CH:29]=[CH:28][CH:27]=3)/[C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)=[CH:11][CH:10]=1

参加物

5

反応物 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 178452787HCID 178452787、化合物

生成物 1

HCID 178507732HCID 178507732、化合物

試薬・触媒・溶媒 2

HCID 3283Diethyl Ether溶媒HCID 6344Dichloromethane溶媒

反応条件

温度
40 °C

実験手順

1.7 g (4 mmol) of (Z)-3-[1-(4-tert.butoxycarbonylamino-phenylamino)-1-phenyl-methylidene]-2-indolinone are suspended in 15 ml of dichloromethane and after the addition of 35 ml of ethyl acetate/hydrogen chloride for 18 hours at ambient temperature and stirred for 2 hours at 40° C. After cooling the mixture is diluted with ether and the precipitate is suction filtered. The residue is divided between sodium chloride solution and methylene chloride, the organic extracts are dried and concentrated by evaporation.

後処理

  1. temperatureAfter cooling the mixture
  2. filtrationfiltered
  3. customthe organic extracts are dried
  4. concentrationconcentrated by evaporation

出典と根拠

ORDレコード
ord-8fa7049170a2422889d0449785b89eb9
出典データセット
uspto-grants-2005_02
特許番号
US06855710B2

関連ノート

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