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Sodium hydride → 3-(3,5-Di-tert-butyl-4-hydroxyphenyl)-1-n-octadecylpyrrolidine-2,5-dione
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium hydride | HCID 24758 | — |
| 反応物 | 2,6-Di-tert-butylphenol | HCID 31405 | — |
| 反応物 | 1-octadecyl-1H-pyrrole-2,5-dione | HCID 87118 | — |
| 溶媒 | tert-Butanol | HCID 6386 | — |
| 生成物 | 3-(3,5-Di-tert-butyl-4-hydroxyphenyl)-1-n-octadecylpyrrolidine-2,5-dione | HCID 14148376 | 37% |
反応手順
This compound is prepared by the procedure of Example 1 from 2.40 g (0.1 mol) of sodium hydride, 20.63 g (0.1 mol) of 2,6-di-tert-butylphenol, and 34.96 g (0.1 mole) of N-n-octadecylmaleimide in tert-butyl alcohol. The residue is purified by dry-column chromatography (3:1 heptane:ethyl acetate eluent) followed by recrystallization from petroleum ether to give 20.5 g (37%) of a white solid: mp 70°-73° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04709050 |
| 出典データセット | uspto-grants-1987_11 |
| ORD ID | ord-bc9998d89c954ab68c5338046a6d93d4 |
| 出典メモ | uspto-grants-1987_11 |