Sodium hydride → 3-(3,5-Di-tert-butyl-4-hydroxyphenyl)-1-n-octadecylpyrrolidine-2,5-dione

HRID 247613

反応式

HRID 247613 の反応式
[H-].[Na+].[C:3]([C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([C:13]([CH3:16])([CH3:15])[CH3:14])[C:8]=1[OH:17])([CH3:6])([CH3:5])[CH3:4].[CH2:18]([N:36]1[C:40](=[O:41])[CH:39]=[CH:38][C:37]1=[O:42])[CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH3:35]>C(O)(C)(C)C>[C:13]([C:9]1[CH:10]=[C:11]([CH:39]2[CH2:38][C:37](=[O:42])[N:36]([CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH3:35])[C:40]2=[O:41])[CH:12]=[C:7]([C:3]([CH3:6])([CH3:5])[CH3:4])[C:8]=1[OH:17])([CH3:16])([CH3:15])[CH3:14]

参加物

5

反応物 3

HCID 24758Sodium hydrideHCID 314052,6-Di-tert-butylphenolHCID 871181-octadecyl-1H-pyrrole-2,5-dione

生成物 1

HCID 141483763-(3,5-Di-tert-butyl-4-hydroxyphenyl)-1-n-octadecylpyrrolidine-2,5-dione収率 37%

試薬・触媒・溶媒 1

HCID 6386tert-Butanol溶媒

実験手順

This compound is prepared by the procedure of Example 1 from 2.40 g (0.1 mol) of sodium hydride, 20.63 g (0.1 mol) of 2,6-di-tert-butylphenol, and 34.96 g (0.1 mole) of N-n-octadecylmaleimide in tert-butyl alcohol. The residue is purified by dry-column chromatography (3:1 heptane:ethyl acetate eluent) followed by recrystallization from petroleum ether to give 20.5 g (37%) of a white solid: mp 70°-73° C.

後処理

  1. customThe residue is purified by dry-column chromatography (3:1 heptane:ethyl acetate eluent)
  2. customfollowed by recrystallization from petroleum ether

出典と根拠

ORDレコード
ord-bc9998d89c954ab68c5338046a6d93d4
出典データセット
uspto-grants-1987_11
特許番号
US04709050

関連ノート

読み込み中…