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Methyl 3-(dimethylamino)acrylate → Methyl 4-(2,3-dichlorophenyl)-1H-pyrrole-3-carboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methyl 3-(dimethylamino)acrylate | HCID 566587 | — |
| 反応物 | Sodium ethoxide | HCID 2723922 | — |
| 反応物 | Ethanone, 2-amino-1-(2,3-dichlorophenyl)-, hydrochloride | HCID 22151845 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | Methyl 4-(2,3-dichlorophenyl)-1H-pyrrole-3-carboxylate | HCID 15087831 | — |
反応手順
10.7 g of 2,3-dichlorophenacylamine hydrochloride and 6 g of methyl 3-dimethylaminoacrylate are heated for 2 hours under reflux in 120 ml of ethanol. Then a solution of 4 g of sodium ethylate in 40 ml of ethanol is added dropwise and the reaction mixture is heated for another hour under reflux. The reaction mixture is then concentrated by evaporation and the oily residue is purified by column chromatography (silica gel; elution with a 3:1 mixture of toluene/ethyl acetate. Melting point: 205°-206° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04709053 |
| 出典データセット | uspto-grants-1987_11 |
| ORD ID | ord-750983bedfe549e1acd00975d504a47a |
| 出典メモ | uspto-grants-1987_11 |