Acetone → 1,2:3,4:5,6-Tris-O-(1-methylethylidene)hexitol

HRID 247639ノート

反応式

HRID 247639 の反応式
[CH2:1]([OH:12])[C@H:2]([C@H:4]([C@@H:6]([C@@H:8]([CH2:10][OH:11])[OH:9])[OH:7])[OH:5])[OH:3].[CH3:13][C:14]([CH3:16])=O>>[CH3:13][C:14]1([CH3:16])[O:9][CH:8]([CH:6]2[O:7][C:2]([CH3:4])([CH3:1])[O:5][CH:4]2[CH:2]2[O:3][C:8]([CH3:10])([CH3:6])[O:12][CH2:1]2)[CH2:10][O:11]1

参加物

3

反応物 2

HCID 180AcetoneHCID 6251Mannitol

生成物 1

HCID 3165221,2:3,4:5,6-Tris-O-(1-methylethylidene)hexitol

実験手順

1,2:3,4:5,6-Tri-o-isopropylidene-d-mannitol is prepared by rapidly stirring with a mechanical stirrer, of 40 g of mannitol and 500 ml of anhydrous acetone in the presence of 4.0 ml of concentrated (18M) sulfuric acid as a catalyst for 24 hours in a 2 liter flask. The sulfuric acid is neutralized with about 6.8 g anhydrous sodium carbonate and the acetone is evaporated by vacuum distillation at about 30° C. The remaining yellowish oil is diluted with an equal volume of cold water in order to provide the crystalline product. The crystals are filtered, dried, and used without further purification.

後処理

  1. concentrationof concentrated (18M) sulfuric acid as a catalyst for 24 hours in a 2 liter flask
  2. customthe acetone is evaporated by vacuum distillation at about 30° C
  3. additionThe remaining yellowish oil is diluted with an equal volume of cold water in order
  4. customto provide the crystalline product
  5. filtrationThe crystals are filtered
  6. customdried
  7. customused without further purification

出典と根拠

ORDレコード
ord-5e48a3d4b11b49e5841c760cbf362875
出典データセット
uspto-grants-1987_11
特許番号
US04709059

反応ノート

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