4-Hydroxybenzoic Acid → Benzoic acid, 4-((1-oxodecyl)oxy)-

HRID 247802

反応式

HRID 247802 の反応式
[OH:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[CH:4][CH:3]=1.[C:11](Cl)(=[O:21])[CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH3:20].CN(C1C=CC=CN=1)C.Cl>C(Cl)Cl.O.C(N(CC)CC)C>[CH2:12]([C:11]([O:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[CH:4][CH:3]=1)=[O:21])[CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH3:20]

参加物

8

反応物 4

HCID 1354-Hydroxybenzoic AcidHCID 313Hydrochloric AcidHCID 218852-DimethylaminopyridineHCID 66982Decanoyl chloride

生成物 1

HCID 3608562Benzoic acid, 4-((1-oxodecyl)oxy)-収率 42.5%

試薬・触媒・溶媒 3

HCID 962Water溶媒HCID 6344Dichloromethane溶媒HCID 8471Triethylamine溶媒

実験手順

A solution of 4-hydroxybenzoic acid (3 g), decanoic acid chloride (4.3 g), triethylamine (2.4 g) and dimethylaminopyridine (0.2 g) in methylene chloride (50 ml) was stirred at room temperature for 24 hours, and then poured in water. The solution was neutralized with dilute aqueous hydrochloric acid solution and extracted with dimethyl ether. The extracted product was dried over anhydrous magnesium sulfate and distilled to remove the solvent. The residue was washed enough with hexane to obtain the titled compound (2.7 g).

後処理

  1. extractionextracted with dimethyl ether
  2. dry with materialThe extracted product was dried over anhydrous magnesium sulfate
  3. distillationdistilled
  4. customto remove the solvent
  5. washThe residue was washed enough with hexane

出典と根拠

ORDレコード
ord-081baeb5b5c44533a76afd5b27c1e8e0
出典データセット
uspto-grants-1993_05
特許番号
US05207947

関連ノート

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