Hydrochloric Acid → 2-Fluoro-4-n-tridecanoyloxybenzoic acid

HRID 247804

反応式

HRID 247804 の反応式
[F:1][C:2]1[CH:10]=[C:9]([OH:11])[CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[C:12](Cl)(=[O:25])[CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH3:24].CN(C1C=CC=CN=1)C.Cl>ClCCl.C(N(CC)CC)C>[F:1][C:2]1[CH:10]=[C:9]([O:11][C:12](=[O:25])[CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH3:24])[CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5]

参加物

7

反応物 4

HCID 313Hydrochloric AcidHCID 218852-DimethylaminopyridineHCID 87288Tridecanoyl chlorideHCID 27833982-Fluoro-4-hydroxybenzoic Acid

生成物 1

HCID 193652682-Fluoro-4-n-tridecanoyloxybenzoic acid収率 59.4%

試薬・触媒・溶媒 2

HCID 6344Dichloromethane溶媒HCID 8471Triethylamine溶媒

実験手順

To a solution of 2-fluoro-4-hydroxybenzoic acid (1.4 g) and triethylamine (1.0 g) in dichloromethane (40 ml) were added tridecanoyl chloride (2.0 g) and dimethylaminopyridine (0.2 g). The solution was stirred at room temperature for about 20 hours and thereto was added dilute aqueous hydrochloric acid solution. The organic layer was separated by a funnel and distilled to remove the solvent. The residue was washed with n-hexane and dried to obtain the titled compound (about 1.8 g).

後処理

  1. customThe organic layer was separated by a funnel
  2. distillationdistilled
  3. customto remove the solvent
  4. washThe residue was washed with n-hexane
  5. customdried

出典と根拠

ORDレコード
ord-01c87d2080664374a114683782c76fb9
出典データセット
uspto-grants-1993_05
特許番号
US05207947

関連ノート

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