関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Sodium hydride | HCID 24758 | — |
| 反応物 | Acetamide, N-[2,6-bis(1-methylethyl)phenyl]-2-bromo- | HCID 12149064 | — |
| 反応物 | Dibenzylphosphite | HCID 21904359 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | Sodium dibenzylphosphite | HCID 23706462 | — |
反応手順
A solution of sodium dibenzylphosphite is prepared by the addition of a 60% mineral oil dispersion of sodium hydride (0.4 g, 0.01 mol) to a solution of dibenzyl phosphite (2.62 g, 0.01 mol) in dry tetrahydrofuran (20 mL). To the resultant solution is added N-[2,6-bis(1-methylethyl)phenyl]-2-bromoacetamide (2.98 g, 0.01 mol) and the mixture is stirred at 50° C. overnight. The reaction mixture is filtered and concentrated. Flash chromatography and crystallization affords 1.4 g of the title compound; mp 117°-119° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US05208224 |
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| 出典データセット | uspto-grants-1993_05 |
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| ORD ID | ord-a55b806b45ab4d79833bdc4756835658 |
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| 出典メモ | uspto-grants-1993_05 |
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