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N-[2,6-bis(1-methylethyl)phenyl]-2-[phenylmethyl]amino-acetamide → HCID 15452514、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | N-[2,6-bis(1-methylethyl)phenyl]-2-[phenylmethyl]amino-acetamide | HCID 19764427 | — |
| 触媒 | Palladium | HCID 23938 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | HCID 15452514 | HCID 15452514 | 80.2% |
反応手順
To a solution of N-[2,6-bis(1-methylethyl)phenyl]-2-[(phenylmethyl)amino]acetamide (Example V) (0.80 g, 2.5 mmol) in methanol (10 mL) is added 20% Pd/C (0.1 g). The mixture is stirred under an atmosphere of hydrogen for 20 hours. After filtration and concentration, flash chromatography (ethyl acetate) affords 0.47 g of the title compound as a white solid; mp 88°-95° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05208224 |
| 出典データセット | uspto-grants-1993_05 |
| ORD ID | ord-54a7e6c6256c4bfead7a8a1347cd0de0 |
| 出典メモ | uspto-grants-1993_05 |